Current Cancer Research 1998 by Prof. Dr. Dr. h.c.mult. Harald zur Hausen (auth.)

By Prof. Dr. Dr. h.c.mult. Harald zur Hausen (auth.)

From the contents: - Carcinogenicity and Differentiation - Tumor mobile rules - melanoma danger elements and melanoma Prevention - Diagnostic and Experimental remedy - Radiological Diagnostic and remedy - utilized Tumor Virology - Tumor Immunology - Genom study and Bio-information

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These anticancer drugs are widely used in the clinical treatment of hematological cancers, ovarian cancer, and mammary cancer. Effective concentrations of these anticancer agents may be prevented by the action of MDR1 Pglycoprotein. lt has been recognized more recently that MDR1 P-glycoprotein transports not only exogenaus cytotoxic drugs into the extracellular space but also a number of structurally different endogenaus lipophilic compounds. 51 Another membrane protein with properties of an ATP dependent membrane pump causing resistance to a variety of cytotoxic agents has been cloned and sequenced from lung cancer cells in 1992 by a group of Canadian scientists.

Furthermore, the trogs need not be sacriticed since they lay the eggs into the aquarium. To discover novel developmental control genes, genes are taken randomly from a gene library and the distribution of their gene products, their mRNA, is analyzed in the whole embryo using a special staining procedure. Genes showing a particularly interesting staining pattern are then selected and analyzed more caretully. ln cooperation with Dr. Hajo Delius the sequence ot 41 the deoxyribonucleic acid (DNA) of these genes is determined and compared to the sequence of known genes that are compiled in databases.

Dozens of developmental control genes have been indentified in this manner. There are developmental control genes whose micoinjection Ieads to the formation of siamese twins, which have two heads and trunks. These genes are way up in the hierarchy of embryonie development and serve as main switches, initiating and organizing embryogenesis. The later a gene acts du ring development the more restricted its regulative properties typically are. While early expressed developmental control genes can induce whole siamese twins, the late genes will only be able to induce for example muscle tissue.

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