By A. J. Shatkin, A. K. Banerjee, G. W. Both (auth.), Heinz Fraenkel-Conrat, Robert R. Wagner (eds.)
The time turns out ripe for a severe compendium of that phase of the organic universe we name viruses. Virology, as a technological know-how, having handed only in the near past via its descriptive section of naming and num bering, has most likely reached that level at which quite few new actually new-viruses may be came upon. caused through the highbrow probes and strategies of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the sphere has skilled a real info explosion. Few critical makes an attempt were made to chronicle those occasions. This entire sequence, that allows you to include a few 6000 pages in a complete of approximately 22 volumes, represents a dedication by means of a wide crew of lively investigators to research, digest, and expostulate at the nice mass of knowledge when it comes to viruses, a lot of that's now amorphous and disjointed, and scattered all through a large literature. during this approach, we are hoping to put the total box in viewpoint, and to boost a useful reference and sourcebook for researchers and scholars in any respect degrees. This sequence is designed as a continuum that may be entered at any place, yet which additionally offers a logical development of constructing evidence and built-in concepts.
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Extra info for Comprehensive Virology 10: Regulation and Genetics Viral Gene Expression and Integration
Further in vitro studies with initiator tRNA acylated with [35 S]methionine should help to establish whether structural and nonstructural proteins are synthesized directly from different initiation sites in the 49 S RNA or if a single site, presumably near the 5' end of the genome RNA, is used to make a polyprotein that is subsequently cleaved. , initiation sites for capsid protein and envelope precursor polypeptide with cleavage of the latter to form EI and E2. 2. 1. la. Rhabdoviruses Proteins Among the various rhabdoviruses including those of mammals, plants, fish, and insects, vesicular stomatitis virus (VSV) has been most extensively studied (Wagner, 1975).
Does not function as viral messenger RNA. It hybridizes well with the RNA products synthesized in vitro by the virion-associated RNA polymerase (Chow and Simpson, 1971) and with the RNA isolated from polysomes of infected cells (Pons, 1973). The influenza structural proteins consist of about seven polypeptides with an apparent molecular weight range of 25~94K.
Consequently, a spectrum of newly formed virus-specific polypeptides can be readily detected by SDS-polyacrylamide gel analysis of radioisotope-labeled infected cells. Both noncapsid viral proteins (NCVP) and virion structural proteins (VP) ranging in size from about 7K to as high as 200K daltons have been identified. Their combined molecular weight far exceeds the expected coding capacity of the viral genome, a paradox resolved by the suggestion that the multitude of picornavirus polypeptides are generated from a larger "polyprotein" by posttranslational cleavage (Summers and Maizel, 1968; Jacobson and Baltimore, 1968; Holland and Kiehn, 1968).