Chromatographic Methods in Metabolomics by Tuulia Hyotylainen, Susanne Wiedmer, Roger M Smith, Tuulia

By Tuulia Hyotylainen, Susanne Wiedmer, Roger M Smith, Tuulia Hyötyläinen, Ian D Wilson, Katja Dettmer, Akiyoshi Hirayama, Tiina Sikanen, Matej Oresic

This is a vital guide for any laboratory trying to embark on a metabolomics learn programme and contains the basics of chromatography along the most recent advancements within the field.

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Analyser Mass range (m/z, Â10–3) Resolving Scan power, Mass accuracy rate Resolution FWHM (Hz) (Â10–3) (ppm) (Dm/z) 44 14/10/2013 09:21:42. 5–4 105 À 106 LC, GC Chapter 3 A low mass resolution analyser. DC and RF potentials are applied to four parallel rods, each opposite pair being electrically connected. These potentials are varied in order to provide a mass filter where ions of a chosen mass have trajectories of amplitude less than half the radius of the quadrupoles and traverse the mass analyser, whereas ions of lower and higher mass are lost by collisions with the rods.

The selection of the MS instrument depends on both the chromatographic system and the goals of the analysis. For example, in global metabolic profiling, it is usually necessary to determine the elemental composition of specific unknown metabolite and therefore MS with high-resolution accurate mass determination (HRAM), typically together with the capability of tandem mass measurements for structural characterization, is required. High resolution also permits the determination not just of the elemental composition but even the isotopic ratios of unknown compounds.

Naraynan, H. Wisser and B. Zawta, Diagnostic Samples: from the Patient to the Laboratory, 4th edn, Wiley-VCH, Weinheim, 2009. 4. W. Gronwald, M. S. Klein, H. Kaspar, S. R. Fagerer, N. Nu¨rnberger, K. Dettmer, T. Bertsch and P. J. Oefner, Anal. , 2008, 80, 9288. 5. W. B. Dunn, D. Broadhurst, P. Begley, E. Zelena, S. Francis-McIntyre, N. Anderson, M. Brown, J. D. Knowles, A. Halsall, J. N. Haselden, A. W. Nicholls, I. D. Wilson, D. B. Kell, R. Goodacre and Human Serum Metabolome (HUSERMET) Consortium, Nat.

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