By Arthur D. Loewy, K. Michael Spyer
This distinct textual content relates the dramatic advances of contemporary neurobiology to our realizing of the constitution and serve as of the autonomic fearful process, supplying a transparent view of the crucial neuronal elements concerned with autonomic regulate. The scope is extensive, starting from anatomical pathways and molecular pharmacology to the perceptual traits of autonomic sensation and their power in enhancing habit. crucial history info is reviewed and the latest learn mentioned in a readable, informative demeanour. The textual content is richly illustrated. the 1st six chapters supply a accomplished evaluate of the system's anatomy, body structure, and pharmacology, emphasizing the association and keep an eye on of the autonomic preganglionic neurons and the complexity of important pathways. Later chapters evaluation the autonomic keep watch over of cardiovascular, sexual, urinary, endocrine, and different services. Written through a global team of uncommon scientists, this paintings is a worthwhile source for clinicians, scientists, and graduate scholars within the fields of anatomy, body structure, pharmacology, and neuroscience.
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Additional info for Central Regulation of Autonomic Functions
Desensitization of turkey erythrocyte adenylate cyclase. Journal of Biological Chemistry 259,9742-9749. Sibley, D. , Strasser, R. , Benovic, J. , and Lefkowitz, R. J. (1986). Phosphorylation/dephosphorylation of the β-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. Proceedings of the National Academy of Sciences USA 83, 9408-9412. , and Schumann, H. J. (1971). Influence of cocaine and phenoxybenzamine on noradrenaline uptake and release. Naunyn-Schmiedebergs Archiv fur Pharmakologie 270, 210-214.
1987) found four different genes encoding muscarinic receptors in rat brain: ml, m2, m3, and m4. The sequences of the ml and m2 genes correspond, respectively, to the MI and M2 receptors that were cloned from porcine tissues (see above). Expression of the ml, m3, and m4 types by transfection of cultured cells produced proteins with high affinity for pirenzepine with the rank order of m 1 = m4 > m3. It was suggested that these three receptors would all be classified in the M1 type if pirenzepine were used as the means of classification.
1971). Influence of cocaine and phenoxybenzamine on noradrenaline uptake and release. Naunyn-Schmiedebergs Archiv fur Pharmakologie 270, 210-214. Strasser, R. , Sibley, D. , and Lefkowitz, R. J. (1986). A novel catecholamine-activated adenosine cyclic 3',5'phosphate independent pathway for β-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: Mechanism of homologous desensitization of adenylate cyclase. Biochemistry 25, 1371-1377. Tolbert, M. E. , White A. , and Fain, J.