By T. C. Thompson, S. A. Tahir, L. Li (auth.), Isabelle Mercier, Jean-François Jasmin, Michael P. Lisanti (eds.)
Caveolins are very important structural proteins of Caveolae, small invaginations of the membrane. they've been proven to play an immense function within the pathogenesis of a number of cancers. during this quantity, we are going to normally specialize in the significance of Caveolin-1 in breast, prostate, lung, dermis, colon, pancreatic and mind cancers with additionally a point out of the radical position of Caveolin-3 in breast melanoma.
Read or Download Caveolins in Cancer Pathogenesis, Prevention and Therapy PDF
Similar cancer books
From its creation, oncological chemotherapy has been laden by means of its negative selectivity simply because such a lot antiproliferative medicines are poisonous not just to tumor cells but additionally to special populations of the body’s non-neoplastic cells. the ensuing issues of uncomfortable side effects are compounded through problems in predicting the specified efficiency of chemotherapy in person sufferers.
The Analog capability in melanoma Chemotherapy within the usa and Japan S. ok. Carter Northern California melanoma application, 1801 web page Mill street, construction B, Suite 2 hundred, united states - Palo Alto, CA 94304 The bilateral collaborative application in melanoma learn among Japan and the USA is likely one of the oldest courses of this kind.
- Prostate Cancer
- IASLC Textbook of Prevention and Early Detection of Lung Cancer
- The After Cancer Diet: How to Live Healthier Than Ever Before
- Johns Hopkins Patients' Guide To Kidney Cancer (Johns Hopkins Medicine)
- Advances in Cancer Research (Volume 100)
Extra info for Caveolins in Cancer Pathogenesis, Prevention and Therapy
References 1. Altieri DC (2003) Validating survivin as a cancer therapeutic target. Nat Rev Cancer 3:46–54 2. Anderson RG (1998) The caveolae membrane system. Annu Rev Biochem 67:199–225 3. Ando T, Ishiguro H, Kimura M et al (2007) The overexpression of caveolin-1 and caveolin-2 correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinoma. Oncol Rep 18:601–609 4. Andoh A, Saotome T, Sato H et al (2001) Epithelial expression of caveolin-2, but not caveolin-1, is enhanced in the inflamed mucosa of patients with ulcerative colitis.
Such evidence, however, has generated an intense discussion concerning the precise role of caveolin-1 in cancer, since also a large body of data is available in the literature suggesting that caveolin-1 functions as a tumor suppressor (see subsequent sections). A key objective of this chapter will be to highlight important aspects of this ongoing discussion and reconcile in a working model (see Fig. 3) these different and opposing functions of caveolin-1. In doing so, we will focus our attention mostly on studies dealing with the role of caveolin-1 in colorectal cancer.
Second, a specific understanding of the elements within the protein that are required in vivo for the molecule to act as a tumor suppressor or promote opposing characteristics in a tumor cell is essential. With these insights at hand, we can expect to initiate the design and use of successful caveolin-1-based strategies in the treatment of cancer. G). References 1. Altieri DC (2003) Validating survivin as a cancer therapeutic target. Nat Rev Cancer 3:46–54 2. Anderson RG (1998) The caveolae membrane system.