Caveolins in Cancer Pathogenesis, Prevention and Therapy by T. C. Thompson, S. A. Tahir, L. Li (auth.), Isabelle

By T. C. Thompson, S. A. Tahir, L. Li (auth.), Isabelle Mercier, Jean-François Jasmin, Michael P. Lisanti (eds.)

Caveolins are very important structural proteins of Caveolae, small invaginations of the membrane. they've been proven to play an immense function within the pathogenesis of a number of cancers. during this quantity, we are going to normally specialize in the significance of Caveolin-1 in breast, prostate, lung, dermis, colon, pancreatic and mind cancers with additionally a point out of the radical position of Caveolin-3 in breast melanoma.

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References 1. Altieri DC (2003) Validating survivin as a cancer therapeutic target. Nat Rev Cancer 3:46–54 2. Anderson RG (1998) The caveolae membrane system. Annu Rev Biochem 67:199–225 3. Ando T, Ishiguro H, Kimura M et al (2007) The overexpression of caveolin-1 and caveolin-2 correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinoma. Oncol Rep 18:601–609 4. Andoh A, Saotome T, Sato H et al (2001) Epithelial expression of caveolin-2, but not caveolin-1, is enhanced in the inflamed mucosa of patients with ulcerative colitis.

Such evidence, however, has generated an intense discussion concerning the precise role of caveolin-1 in cancer, since also a large body of data is available in the literature suggesting that caveolin-1 functions as a tumor suppressor (see subsequent sections). A key objective of this chapter will be to highlight important aspects of this ongoing discussion and reconcile in a working model (see Fig. 3) these different and opposing functions of caveolin-1. In doing so, we will focus our attention mostly on studies dealing with the role of caveolin-1 in colorectal cancer.

Second, a specific understanding of the elements within the protein that are required in vivo for the molecule to act as a tumor suppressor or promote opposing characteristics in a tumor cell is essential. With these insights at hand, we can expect to initiate the design and use of successful caveolin-1-based strategies in the treatment of cancer. G). References 1. Altieri DC (2003) Validating survivin as a cancer therapeutic target. Nat Rev Cancer 3:46–54 2. Anderson RG (1998) The caveolae membrane system.

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