Capillary Electrophoresis - Mass Spectrometry (CE-MS) by Gerhardus de Jong

By Gerhardus de Jong

This monograph deals the reader a whole evaluate on either rules and purposes of CE-MS. beginning with an introductory bankruptcy on detection in CE, additionally similar and extra really good strategies resembling electrophoretic and chromatographic preconcentration are mentioned. a different emphasis is wear CE-MS interfaces, that are defined intimately. In a separate bankruptcy, recognition is paid to sheath-liquid interfacing. The advancements and probabilities of microchip CE-MS also are defined. purposes to all suitable components are mentioned in specified chapters, every one written by means of specialists within the respective fields.
in addition to purposes in pharmaceutical research and bioanalysis, contemporary implementations in nutrition technology, forensic research, research of intact proteins, metabolomics and proteomics are highlighted. MS is a superbly applicable detection method for CE, as effective separation is coupled to delicate and choice detection. additionally, MS delivers constitution info at the separated compounds. CE-MS has now been constructed right into a robust hyphenated procedure complementary to LC-MS. This monograph is an specific resource of information for everybody facing and attracted to CE-MS

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8). When different CAs migrate to their pI between the anolyte solution and catholyte solution, they create the pH gradient; this allows the amphoteric biomolecules to be focused and separated into sharp zones according to their respective pIs [27, 69]. cIEF with MS is a powerful combination since it offers information about both the pI and the mass-to-charge ratio of the amphoteric analytes. The process of cIEF-MS always involves two steps: first, a focusing step with the mixture of CAs and second, a mobilization step.

For a long time, the sheath-flow interface was the only interface for CE-MS available commercially; only recently, a novel sheathless design from Moini [5] was introduced to the market by AB-SCIEX. This is also reflected in the literature with the vast majority of CE-MS publications reporting the application of sheath-flow interfaces. Detailed descriptions Capillary Electrophoresis–Mass Spectrometry (CE-MS): Principles and Applications, First Edition. Edited by Gerhardus de Jong. © 2016 Wiley-VCH Verlag GmbH & Co.

86, 6331–6336. , and Guttman, A. (2015) Rapid level-3 characterization of 87. 88. 89. 90. 91. 92. 93. therapeutic antibodies by capillary electrophoresis electrospray ionization mass spectrometry. J. Chromatogr. , 53, 443–449. J. (2014) Capillary-electrophoresis mass spectrometry for the detection of carbapenemases in (multi-)drugresistant Gram-negative bacteria. Anal. , 86, 9154–9161. -X. (2014) Differential detection of Rhizoma coptidis by capillary electrophoresis electrospray ionization mass spectrometry with a nanospray interface: CE and CEC.

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