By Valda M. Craddock
The booklet bargains in short with the traditional constitution, functioning and biochemistry of the esophagus and with the histological and genetic alterations accompanying the advance of esophageal melanoma in people and animals. elements implicated in inflicting esophageal melanoma are defined relating to its very dramatic epidemiology. hence nutritional deficiencies and intake of meals infected by means of Fusaria mycotoxins are mentioned in reference to the tremendous excessive prevalence of the illness in definite sharply demarcated areas in China and South Africa, and alcohol and tobacco use are mentioned in terms of the epidemiology in Europe and united states. different risks pointed out contain opium in Iran, betel nut in Asia and bracken in Japan. the only workforce of chemical compounds identified to be very powerful esophageal cancer causing agents in animal experiments, the nitrosamines, are defined specially by way of the frequent human publicity.
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Extra info for Cancer of the Esophagus: Approaches to the Etiology (Cambridge Monographs on Cancer Research)
And Milne, G. (1978) Histochem. J. 10, 159-170. The light and electron microscopic distribution of acid phosphatase activity in human esophageal epithelium. L. F. L. ) New York: McGraw-Hill, pp. 247-307. Anatomy. E. (1952) /. Anat. 86, 431-442. Developmental changes in the esophageal epithelium of man. Lazarides, E. (1982) Ann. Rev. Biochem. 51, 519-550. Intermediate filaments: a chemically homogeneous, developmentally regulated class of proteins. C. M. (1964) In: Advances in Biology of Skin, vol.
The cellular composition of the affected region of Barrett's esophagus varies in different parts of the lesion and in different patients. There is convincing evidence that esophageal adenocarcinoma, which is rare in the general population, occurs at high incidence with Barrett's esophagus (Ming 1984). As might be expected from the association between alcohol consumption and reflux, in many series of Barrett's esophagus patients, consumption of tobacco and alcohol was high (Gillen et al. 1989). Other case-control studies, however, have suggested that tobacco and alcohol were unlikely to play a major role in the etiology of High-risk diseases 25 Barrett's esophagus (Levi et al.
1980). Detailed studies of mass surveys have been presented by many authors (Pfeiffer 1982). Chronic esophagitis While the occurrence of hyperplasia at some stage during the course of carcinogenesis was fairly rapidly established, the generality of chronic esophagitis as a precursor lesion in high-risk populations was more debatable. One of the earliest reports of a high incidence of chronic esophagitis was from the high-cancer population in Northern Iran (Kmet et al. 1972). In this population chronic esophagitis occurred frequently even in the young age groups (15-24 years old), and therefore was probably due to widespread damage to the esophagus which occurred from an early age.