Cancer Drug Discovery: Science and History by Kyu-Won Kim, Jae Kyung Roh, Hee-Jun Wee, Chan Kim

By Kyu-Won Kim, Jae Kyung Roh, Hee-Jun Wee, Chan Kim

The reader will find a finished and multifaceted assessment of the background of the advance of anticancer medications deeply encouraged through the cellphone idea of melanoma and destiny instructions for the improvement of recent anticancer medicines. First, this booklet records the clinical growth in organic technology over the past 70 years and the impression this growth had in melanoma examine. Summaries and charts of vital discoveries whole this review. additionally, this booklet outlines the method of anticancer drug improvement with a spotlight at the attribute drug teams of every period, with regards to developments of chemistry and organic sciences. This e-book additionally offers short mechanism of motion of substances, illustrated via entire timelines and conceptual cartoons. This publication ultimately sums up the restrictions of the present anticancer drug improvement and seeks new instructions for anticancer drug discovery, contemplating below the systemic view of cancer.

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Clin Cancer Res 19:3360–3368 19. Alberts B, Johnson A, Lewis J et al (2002) Molecular biology of the cell. 4th ed. Garland Science, New York 20. Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420–1428 21. Pollard JW (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4:71–78 22. Goldman B, DeFrancesco L (2009) The cancer vaccine roller coaster. Nat Biotechnol 27:129–139 23. Gyrd-Hansen M, Meier P (2010) IAPs: from caspase inhibitors to modulators of NF-kappa B, inflammation and cancer.

1). Thus, cancer was introduced into the field of science, was scientifically defined, and became an object of study. In 1845, J. H. Bennett was the first to discover abnormal proliferation of leukocytes in blood. Later, in 1847, R. C. Virchow observed hazy pus-like characteristics in blood and named this disease “leukemia” (from the Greek word leukos, meaning “white”). Fig. -W. 1007/978-94-024-0844-7_2 25 26 2 Advancement of the Science and History of Cancer and Anticancer Drugs At this point in time, leukemia was the main focus of early cancer research and anticancer drug development.

The importance of studying genes became widely acknowledged, and in 1938, W. Weaver named the research field that targets molecular substances in the cell, including genes, “molecular biology” [11]. Subsequently, the research areas of bioactive substances at the molecular level, including genes in the cell, were developed and defined. As the research target became clearer, O. T. Avery, C. M. MacLeod, and M. McCarty reported the results of their 1944 study that proved that DNA is the intracellular material of the gene.

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