By Gary Whitman MD
Univ. of Texas M.D. Anderson melanoma heart, Houston. themes contain mammographic-sonographic correlation; breast ultrasound MR imaging correlation; ultrasound-guided breast biopsies; cysts, cystic lesions, and papillary lesions; sonography of ductal carcinoma in situ; and extra. For clinicians.
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Additional resources for Ultrasound Clinics Breast Cancer
42] Paik S, Shak S, Tang G, et al. Expression of the 21 genes in the Recurrence Score assay and tamoxifen clinical beneﬁt in the NSABP study B-14 of node negative, estrogen receptor positive breast cancer [abstract 510]. J Clin Oncol 2005;23(16s):6s.  Saphner T, Tormey DC, Gray R. Annual hazard rates of recurrence for breast cancer after primary therapy. J Clin Oncol 1996;14(10):2738–46.  Mamounas E, Jeong JH, Wickerham L, et al. Beneﬁt from exemestane (EXE) as extended adjuvant therapy after 5 years of tamoxifen (TAM): intent-to-treat analysis of NSABP B33 [abstract 49].
Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation. N Engl J Med 2001; 345(3):159–64. Surg Clin N Am 87 (2007) 317–331 Prophylactic Mastectomy Shaheen Zakaria, MD, Amy C. Degnim, MD* Department of Surgery, Mayo Clinic and Mayo Foundation, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA With availability of genetic testing and development of statistical models for risk stratiﬁcation, more women are being identiﬁed as having an increased risk for breast cancer.
Subset analysis of geneticallytested NSABP P-1 participants demonstrated that tamoxifen does not reduce breast cancer risk in BRCA1 gene mutation carriers; however, it does appear to oﬀer some chemoprevention beneﬁt in BRCA2 mutation carriers . This is consistent with prior studies revealing that BRCA2 mutation-associated tumors are similar in histopathology to sporadic breast cancer, whereas BRCA1 cancers are more likely to be estrogen receptor-negative and aneuploid. The ideal selective estrogen receptor modulator (SERM) would retain antiproliferative activity in the breast, but without subjecting the patient to the negative risks.