Biological and Hormonal Therapies of Cancer by Kenneth A. Foon (auth.), Kenneth A. Foon M.D., Hyman B. Muss

By Kenneth A. Foon (auth.), Kenneth A. Foon M.D., Hyman B. Muss M.D. (eds.)

This quantity, organic and Hormonal cures of melanoma, that's a part of the sequence melanoma remedy and examine, provides chosen new info pertaining to biologic and hormonal treatment of melanoma. we now have tried to supply the reader with themes of significant curiosity rapidly. there's renewed curiosity in biologic treatment of melanoma. chapters evaluation the position of interferon within the hematologic malignancies and in good tumors. Vaccine treatments have come to the leading edge of melanoma treatment re­ cently, and chapters technique varied suggestions of vaccine cures; one stories the mobile vaccine remedies and one other the anti-idiotype ap­ proach. The hormonal remedy chapters specialise in present makes use of of endocrine treatment in endometrial, breast, and prostate melanoma. furthermore, hormonal thoughts for the prevention of breast melanoma and endometrial melanoma, together with excit­ ing details with regards to phytochemicals, are provided. the consequences of tamoxifen on endometrium is a subject of significant curiosity and is mentioned intimately. ultimately, there's a bankruptcy on estrogen receptor expression and regula­ tion in human breast melanoma. those chapters are all written by means of specialists within the box and comprise well timed and suitable info of curiosity to laboratory and medical scientists and practitioners alike. Biologic and endocrine remedies symbolize significant components of melanoma examine curiosity. the appearance of more moderen biologic cures, together with new antibody­ distinct remedies, and using biologics as tumor modulators to reinforce the results of different remedy regimens is an exploding street of research.

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J Clin Oncol 9:1806--1810. 13. Pazdur R, Ajani JA, Patt YZ, et al. 1993. Phase II evaluation of recombinant alpha-2ainterferon and continuous infusion fluorouracil in previously untreated metastatic colorectal adenocarcinoma. Cancer 71:1214--1218. 14. John WJ, Neefe JR, Macdonald JS, et al. 1993. 5-fluorouracil and interferon-alpha-2a in advanced colorectal cancer: Results of two treatment schedules. Cancer 72:3191-3195. 15. Pavlick AC, DelGaudio D, Harper H, Rosenbluth R, Pecora AL. 1992. Salvaged therapy with continuous infusion 5-fluorouracil and alpha interferon in patients with colorectal cancer.

Toxicity, mainly stomatitis and diarrhea, was moderate but was considered manageable. Median time to treatment failure ranged from 8 to 16 months. Investigators have published results of phase II studies utilizing both bolus and infusion fluorouracil, leucovorin, and interferon [23]. The response rate was comparable to trials without interferon. However, toxicity was significantly worse. The recently completed NSABP trial utilized 5-FU, leucovorin, and interferon for the treatment of stage II and III colon cancer after definitive resection; results are shown in figure 1.

21. Grem JL, Jordan E, Robson ME, et al. 1993. Phase II study of fluorouracil, leucovorin and interferon-alfa-2a in metastatic colorectal carcinoma. J Clin Oncol 11:1737-1745. 22. Schmoll JH, Kohne-Wompner CH, Hiddeman W, et al. 1992. Interferon alpha-2b, 5fluorouracil and folinic acid combination therapy in advanced colorectal cancer: preliminary results of a phase IIII trial. Semin Oncol 19 (2, Suppl 3):191-196. 23. Tournigand C, Louvat C, de Gramont A, et al. 1997. Bimonthly high-dose leucovorin and 5fluorouracil 48-hour infusion with interferon-alpha-2a in patients with advanced colorectal cancer.

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