By Lucy Grealy
"I spent 5 years of my existence being taken care of for melanoma, yet considering that then I've spent fifteen years being handled for not anything except taking a look assorted from every person else. It was once the soreness from that, from feeling gruesome, that I continually considered because the nice tragedy of my existence. the truth that I had melanoma appeared minor in comparison."
At age 9, Lucy Grealy was once clinically determined with a very likely terminal melanoma. whilst she lower back to college with a 3rd of her jaw got rid of, she confronted the harsh scoffs of classmates. during this strikingly candid memoir, Grealy tells her tale of significant pain and noteworthy energy with out sentimentality and with massive wit. Vividly portraying the discomfort of peer rejection and the responsible pleasures of desirous to be specified, Grealy captures with exact perception what it truly is like as a baby and younger grownup to be torn among warring impulses: to believe that greater than anything we wish to be enjoyed for who we're, whereas wishing desperately and secretly to be perfect.
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Extra info for Autobiography of a Face
The first published small molecule claimed to restore wild-type conformation to mutant p53 is CP-31398 (78) (Fig. 2A). Foster et al. (1999) have screened a large compound library searching for small molecules that could stabilize the PAb 1620-epitope of wild-type p53 against thermal stress/denaturation. They have used a recombinant p53 DNA-binding domain and an ELISA-based assay (78). CP-31398, the most potent representative of the identified compound classes, has been found to be active in cellular assays.
Nikolova et al. have been able to identify specific second-site mutants and have concluded that the function of p53 mutants could be restored by small molecules that are capable of stabilizing the native p53 structure (65). Finally, semirational protein design (66) and directed evolution (67,68) have helped to generate p53 mutants with wild-type p53 function and increased thermodynamic stability. Nikolova et al. have designed a superstable quadruple mutant M133L/V203A/N239Y/N268D of the p53 DNAbinding domain with second-site suppressor mutations N239Y and N268D that have specifically restored the activity and stability of several oncogenic mutants (66).
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