Arrival of the Fittest: Solving Evolution's Greatest Puzzle by Andreas Wagner

By Andreas Wagner

“Natural choice can safeguard ideas, however it can't create them. Nature’s many innovations—some uncannily perfect—call for traditional ideas that speed up life’s skill to innovate.”

Darwin’s thought of average choice explains how worthy diversifications are preserved over the years. however the greatest secret approximately evolution eluded him. As genetics pioneer Hugo de Vries placed it, “natural choice may possibly clarify the survival of the fittest, however it can't clarify the coming of the fittest.”

Can random mutations over an insignificant 3.8 billion years particularly be chargeable for wings, eyeballs, knees, camouflage, lactose digestion, photosynthesis, and the remainder of nature’s artistic marvels? And if the answer's no, what's the mechanism that explains evolution’s velocity and efficiency?

In Arrival of the Fittest, well known evolutionary biologist Andreas Wagner attracts on over fifteen years of study to offer the lacking piece in Darwin's idea. utilizing experimental and computational applied sciences that have been heretofore unimagined, he has discovered that variations will not be simply pushed unintentionally, yet through a collection of legislation that let nature to find new molecules and mechanisms in a fragment of the time that random version could take.

Consider the Arctic cod, a fish that lives and flourishes inside of six levels of the North Pole, in waters that frequently fall under zero levels. At that temperature, the inner fluids of such a lot organisms become ice crystals. And but, the arctic cod survives via generating proteins that reduce the freezing temperature of its physique fluids, very similar to antifreeze does for a car’s engine coolant. the discovery of these proteins is an archetypal instance of nature’s huge, immense powers of creativity.

Meticulously researched, conscientiously argued, evocatively written, and whole of attention-grabbing examples from the animal state, Arrival of the Fittest bargains up the ultimate puzzle piece within the secret of life’s wealthy diversity.

Publication date: 10/2/2014
Pages: 304

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2 deletion occurred in 26 out of 4,718 cases of schizophrenia and in 79 out of 41,994 controls. 3 deletion was present in seven out of 4,213 cases and in eight out of 39,000 controls. , in the diagnostic and statistical manual [DSMIV]). Need et al. (2009) reported results of a genome-wide analysis of single nucleotide polymorphisms (SNPs) and copy number variants in Schizophrenia. They initially studied a cohort of 1,460 patients and 12,995 controls. They subsequently analyzed 1,073 cases and population-based controls.

Many behaviors in humans and primates involve learning from the previous generation. Varki et al. suggested that intergenerational cultural transfer allowed partial escape from genetic hardwiring and permitted invention and extended developmental plasticity. Accelerated Evolution of Conserved Non-protein Coding Sequences in Humans Prabhakar et al. (2006) searched for human-specific substitutions in 110,549 conserved non-protein coding sequences. They identified 992 elements with an excess of human-specific substitution, 79% more than would be expected by chance.

2007) identified a mutation G/C at -14010 in individuals with lactase persistence in Kenya and Tanzania. They noted the presence of a long stretch of homozygosity of nucleotides in the vicinity of -14010 C consistent with positive selection of this region. Other polymorphisms of interest are T/G at -13915 and C/G at -13907. Ingram et al. (2007) described -13915 G variants in Sudanese cattle-herding groups. These variants exist on different haplotype backgrounds and they are geographically restricted.

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