Apoptosis, Senescence, and Cancer by Scott H. Kaufmann MD, PhD (auth.), David A. Gewirtz, Shawn

By Scott H. Kaufmann MD, PhD (auth.), David A. Gewirtz, Shawn E. Holt, Steven Grant (eds.)

Apoptosis, Senescence and melanoma presents perception into validated practices and study into apoptosis and senescence via completely analyzing novel and rising ideas and examine within the fields of cellphone demise pathways, senescence development arrest, medicines and resistance, DNA harm reaction, and different themes which nonetheless carry mysteries for researchers.

The quantity is split into six effortless to keep on with sections. the 1st is Apoptosis and substitute Modes of mobilephone dying, by way of chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The 3rd half covers DNA harm reaction, Signaling Pathways and Tumorigenesis, whereas the fourth delves into Resistance and Sensitization. The ebook concludes with confirmed melanoma remedies and a bit which seems towards the long run with fresh and constructing melanoma Therapies.

In overall, this quantity offers easy scientists and clinicians with a deeper and extra entire figuring out of the mobile responses of malignancies that could ascertain the effectiveness of remedy, either within the preliminary phases of the sickness in addition to in illness recurrence.

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31. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell 1998; 1:949–57. 32. Ruchaud S, Korfali N, Villa P, et al. Caspase-6 gene knockout reveals a role for Lamin A cleavage in apoptotic chromatin condensation. EMBO J 2002; 21:1967–77. 33. Kothakota S, Azuma T, Reinhard C, et al. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 1997; 278(5336):294–8. Chapter 1 / The Intrinsic Pathway of Apoptosis 21 34.

156. MacFarlane M, Merrison W, Bratton SB, Cohen GM. Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. J Biol Chem 2002; 277:36611–6. 157. Goyal L. Cell death inhibition: keeping caspases in check. Cell 2001; 104(6):805–8. 158. Srinivasula SM, Hegde R, Saleh A, et al. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature 2001; 410:112–6. 159. Scott FL, Denault JB, Riedl SJ, Shin H, Renatus M, Salvesen GS.

141. Luciano F, Jacquel A, Colosetti P, et al. Phosphorylation of Bim-El by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Oncogene 2003; 22:6785–93. 142. Krajewski S, Krajewska M, Shabaik A, et al. Immunohistochemical analysis of in vivo patterns of Bcl-X expression. Cancer Res 1994; 54:5501–7. 143. Krajewski S, Bodrug S, Krajewska M, et al. Immunohistochemical analysis of Mcl-1 protein in human tissues. Am J Pathol 1995; 146(6):1309–19.

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