Apoptosis in Neurobiology (Frontiers in Neuroscience) by Yusuf A. Hannun, Rose-Mary Boustany

By Yusuf A. Hannun, Rose-Mary Boustany

The speedy development of the research of apoptosis-mechanism-driven, regulated telephone death-has created an pressing desire for trustworthy documentation of the various methods to and strategies of learning some of the elements of the sector. Apoptosis in Neurobiology is a crucial source for researchers during this rising frontier of biomedical examine. This quantity permits the uninitiated neuroscientist highbrow and functional entry to the research of apoptosis, with precise attention to the anxious procedure. the 1st part concentrates on conceptual ways to the examine of apoptosis in neurobiology and its importance to the worried approach. the second one part presents a basic method of equipment and methods within the research of apoptosis as utilized to neurobiology.

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Extra resources for Apoptosis in Neurobiology (Frontiers in Neuroscience)

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59. M. , A role for GAPDH in apoptosis and neurodegeneration, Nat. , 2, 609, 1996. 60. , Overexpression of glyceraldehyde-3-phosphate dehydrogenase is involved in low K+induced apoptosis but not necrosis of cultured cerebellar granule cells, Mol. , 51, 542, 1997. © 1999 by CRC Press LLC 61. , Transglutaminase-catalyzed inactivation of glyceraldehyde-3-phosphate andalphaketoglutarate dehydrogenase complex by polyglutamine domains of pathological length, Proc. Nat. Acad. Sci. , 94,12604, 1997. 62.

9, 1763, 1997. 46. , Lewis, G. , Fisher, S. K. , Apoptotic photoreceptor degeneration in experimental retinal detachment, Invest. Ophthalmol. Vis. , 36, 990, 1995. 47. Nash, M. , Peachey, N. , Li, Z. , Gryczan, C. , Milam, A. , Light-induced acceleration of photoreceptor degeneration in transgenic mice expressing mutant rhodopsin, Invest. Ophthalmol. Vis. , 37, 775, 1996. 48. Abler, A. , Chang, C. , Tso, M. O. and Lam, T. , Photic injury triggers apoptosis of photoreceptor cells, Res. Commun.

59 The mechanism of injury is the ability of the polyglutamine region to aggregate above a certain length of over 35 amino acids, and thereby to influence intracellular metabolism and function through abnormal protein–protein interactions. One enzyme that is affected is glyceraldehyde6-phosphate dehydrogenase (GAPDH), a key enzyme in glycolysis. 60,61 These effects result in an apparent stochastic increase in likelihood for certain sets of neurons to exit by apoptotic cell death, with devastating effects on the nervous system.

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